The grand architectural style of this historic building of the Mediterranean Conference Centre, with its wide long halls, its intricately vaulted ceilings, its rich stone work, combine to provide a singularly rich and striking atmosphere. It was constructed as a hospital in the late 16th Century by the Order of the Knights of St. John of Jerusalem, subsequently also known as the Knights of Malta. The halls of the Sacra Infermeria were lined with comfortable beds for the sick and injured who were treated with the most advanced techniques and fed on silver platters irrespective of their social status.

Among the many halls is the 155metre-long Exhibition Hall which can comfortably accommodate up to 1,100 persons for sit down dinners, the La Vallette Hall, a wonderful banqueting venue which seats 900 guests, as well as the La Cassiere Hall which provides an intimate dining atmosphere for executives or small incentive groups. A mouth-watering variety of catering options are provided by the official caterers, Island Caterers Ltd. The Centre can cater for over 4,000 guests for stand-up cocktail receptions.